Thank you, Ruth. And good afternoon to all those listening in today. Our business continued to accelerate significantly in the first quarter, driven by the best product portfolio in our history, strong execution and robust market demand.
We delivered our sixth straight quarter of double-digit percentage year-over-year revenue growth and record quarterly revenue and profitability. First quarter revenue increased 93% year-over-year to $3.45 billion, with growth in all of our businesses.
Turning to our Computing and Graphics segment. First quarter revenue increased 46% year-over-year to $2.1 billion, led by growth in both Ryzen and Radeon processor sales. In client computing, revenue grew by a significant double-digit percentage year-over-year and increased sequentially as we set records for client processor revenue and ASP. Against the backdrop of strong overall PC demand, our revenue is growing significantly faster than the market, particularly in the ultrathin, gaming and commercial segments. As a result, we believe we gained client processor revenue share in the quarter. Our revenue share has doubled over the last 2 years as we have expanded in the premium products.
In notebooks, we delivered our sixth straight quarter of record mobile processor revenue based on sustained demand for Ryzen 4000 Series processors and the launch of our new Ryzen 5000 Series processors. Ryzen Mobile 5000 Series processor revenue has ramped twice as fast as the prior generation. We expect continued growth in 2021 as the number of notebook platforms powered by our new processors is on track to increase by 50% compared to our prior generation. We're also making good progress in the commercial market as unit shipments of our Ryzen PRO Processors grew by a strong double-digit percentage sequentially. We secured multiple high-volume wins across Fortune 500 aerospace, automotive, electronics and engineering companies in the quarter. And we're well positioned for further growth as we have tripled our commercial notebook design wins with the largest OEMs this year. In graphics, revenue increased by a strong double-digit percentage year-over-year and sequentially, led by channel sales growth as revenue from our high-end Radeon 6000 GPUs more than doubled from the prior quarter. We introduced our Radeon 6700 XT deskstop GPU with leadership 1440p gaming performance in March and are on track for the first notebooks featuring our leading-edge mobile RDNA 2 architecture to launch later this quarter. We expect Radeon 6000 Series GPU sales to grow significantly over the coming quarters as we ramp production. Data center graphics revenue grew year-over-year and sequentially, driven largely by adoption of Instinct accelerators across cloud and HPC customers. We are making great progress on our data center GPU road maps and expect revenue to grow in the second half of the year as we begin the production ramp of our next-generation AMD Instinct GPU to support multiple HPC wins including Frontier, the first U.S. exascale supercomputer. Frontier will use next-generation AMD CPUs, GPUs and software to deliver unprecedented scientific computing and AI capabilities, creating a blueprint for scientific, cloud and enterprise customers to enable exascale-class computing and AI performance over the coming years. Now turning to our Enterprise, Embedded and Semi-Custom segment.
Revenue increased 286% year-over-year to $1.35 billion, driven by strong growth in both semi-custom and EPYC processor sales. Semi-custom revenue declined by a single-digit percentage sequentially, which is better than typical seasonality. We expect semi-custom sales to remain strong throughout 2021, driven by significant demand for the latest generation Sony and Microsoft consoles. In server, we delivered another quarter of record server processor revenue as EPYC processor sales more than doubled year-over-year and grew by a strong double-digit percentage sequentially.
Sales of both our second- and third-gen EPYC processors increased sequentially as growing adoption of our second-gen offerings was complemented by third-gen EPYC processors successfully ramping into production across multiple cloud and enterprise customers. Third-gen EPYC processors offer 25% more performance per watt compared to our previous generation and deliver both per socket and per core leadership across database, ERP, data analytics, Java, virtualization, cloud and supercomputing workloads. Cloud demand was particularly strong in the quarter as Tier 1 providers expanded their EPYC processor deployments to power more of their internal infrastructure and introduced 11 new AMD-powered instances. We expect the number of AMD-powered instances to double by the end of the year to 400 as Microsoft Azure, Amazon, Google, IBM, Oracle and Tencent significantly expand their offerings with third-gen EPYC processors. For the enterprise, Cisco, Dell, HP Enterprise, Lenovo and Supermicro all announced plans to expand their AMD-based offerings with more than 100 new third-gen EPYC processor-powered server platforms that deliver superior performance and total cost of ownership. In HPC, we built momentum with new high-volume wins, including the National Center for Atmospheric Research, Sweden's Institute of Science, as well as a unique on-prem and cloud solution for the United Kingdom's National Weather Modeling Service that will be the world's most powerful weather and climate forecasting supercomputer. Taking a step back, I am very pleased with the progress we have made in our data center business over the last several years as each new EPYC processor generation has ramped significantly faster than the previous generation. We have established AMD as a trusted strategic partner to the largest cloud enterprise and HPC customers based on developing and consistently delivering a leadership multigeneration CPU road map. 2021 marks an inflection point in terms of the scale, ecosystem support and customer adoption of our EPYC and instant processors. In the first quarter, data center product revenue more than doubled year-over-year and represented a high-teens percentage of our overall revenue. We expect data center product revenue to grow significantly as we go through the year, driven by our strong pipeline of new cloud, enterprise and HPC wins. We significantly accelerated our business in the first quarter and now see higher growth for the year, driven by increased customer adoption for our products, overall market strength and additional supply from our supply chain partners. We also passed another major milestone with our pending acquisition of Xilinx in the quarter as shareholders voted overwhelmingly to approve the transaction. We remain on track to close the strategic acquisition by the end of the year.
In closing, we have entered a high-performance computing megacycle with the strongest products and the deepest customer relationships in our history. Our success is built on delivering a consistent cadence of leadership products. We are increasing our R&D investments and aggressively driving our road maps to continue setting the pace of innovation for the industry and deliver best-in-class growth over the coming years. Now I'd like to turn the call over to Devinder to provide some additional color on our first quarter financial performance. Devinder?